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Description

GG522020: IdoA2S-GlcNS6S, 4Na (I2S6)C12H17NNa4O20S3 683. 4 A synthetic heparan sulfate (HS) heparin disaccharide bearing 2 O sulfated iduronic acid (IdoA2S) linked to 2 N,6 O disulfated glucosamine (GlcNS6S), the trisulfated I2S6 sulfation pattern, supplied as the tetrasodium salt. This is the most abundant disaccharide repeat unit of heparin and a key structural element of the antithrombin binding pentasaccharide motif. Heparan sulfate (HS) and heparin are sulfated glycosaminoglycans

C11H20O7 / 264

63 / FZD8(UniProt ID Q9H461) synthetic glycopeptide fragment(Thr541-Ala549

α-D-Gal-Ethyl-Amine

The sugar hydroxyl groups are protected as four acetate esters (Ac4)

/ MUC1(126-149)-STn(140) / Mucin1

31 / A β-D-glucose ligand equipped with a thioacetate-protected thiol linker through a short ethyl spacer

aa length 9) with Sialyl TF (Neu5Acα2-3Galβ1-3GalNAc) at Thr541

Fmoc-Ser(GlcNAc(Ac)3-β-D)-OH

Di-isopropylidene protected)

which can be removed by hydrogenolysis to reveal the free amine for conjugation

2-Thioethyl α-L-rhamnopyranoside

GalNAcα1-O-Thr) equipped with a biotin tag through an amide bond